Department of Pharmacology, Mansfield Road, Oxford OX1 3QT
We are seeking a researcher that can contribute to a project that is using induced pluripotent stem cells (iPSCs) to study astrocyte-to-neuron signalling in a human in vitro model system. The successful applicant will be an enthusiastic, motivated and highly organised scientist possessing excellent laboratory skills and an eagerness to learn new techniques. Good communication skills and the ability to work both as part of a team, and independently, are essential. The post holder will also provide guidance to less experienced members of the research group, including postdocs, research assistants, technicians, plus PhD and project students.
Your main responsibilities include:
• Culturing and experimental investigation of human astrocytes and neurons derived from induced pluripotent stem cells (iPSCs).
• Molecular, optical and pharmacological manipulations of iPSC-derived astrocytes and neurons.
• Design and construct molecular tools for manipulating iPSC-derived astrocytes and neurons. Adapt existing and develop new scientific techniques and experimental protocols where required.
• Conduct biochemical assays on iPSC-derived astrocytes and neurons, including preparation for next generation sequencing.
Essential criteria include:
• Hold a relevant PhD/DPhil (or be close to completion), together with relevant experience.
• Extensive experience in the culturing of human neurons and astrocytes derived from iPSCs.
• Extensive experience in preparing viruses for delivering genes to iPSC- derived neurons and astrocytes.
• Extensive experience with molecular techniques for manipulating and characterising iPSC-derived neurons and astrocytes in vitro.
• Experience in preparing samples for next generation RNA-sequencing and collaborating with bioinformaticians.
The post holder will be a member of Professor Colin Akerman's research group, at the University of Oxford. This is a fixed-term post of up to 30 months, with an initial probationary period, to start on or after 6 January 2025, funded by Alzheimer's Research UK.
The closing date for applications is 12noon on Monday 21 October 2024.
Contact Person : Administrator Vacancy ID : 175853 Contact Phone : Closing Date & Time : 21-Oct-2024 12:00 Pay Scale : RESEARCH GRADE 7 Contact Email : [email protected] Salary (£) : 37,524-42,021