Postdoctoral Researcher / Junior Scientist
Job Field: Science and research, molecular biology and medicine
Postdoctoral position to study RNA modifications and search for RNA-based technological applications
Central European Institute of Technology of Masaryk University (CEITEC MU)
Brno, Czech Republic www. ceitec.eu
About the position:
Applications are invited for a 3–5-year junior research position in Prof. Mgr. Richard Štefl PhD research group to join the RNA4T project - RNA for Therapy, reg. number CZ.02.01.01/00/22008/0004575,” in Programme Johannes Amos Comenius (Czech Republic - The Ministry of Education, Youth and Sports, co- funded by the European Union).
Richard Štefl, holder of an ERC Consolidator grant, has long experience leading research teams and is a leading expert in protein-RNA interactions and structural biology. The Stefl lab is affiliated with the National Centre of Biomolecular Research at Central European Institute of Technology Masaryk University.
RNA4T is a collaborative project with the Weizmann Institute, Israel; the European Molecular Biology Laboratory, EU; the University of Edinburgh, UK; and other relevant partners.
We use an integrated structural biology approach to study interactions between proteins and RNAs to gain structural insights into the assembly and function of RNA processing and degradation machinery.
You will collaborate in Activities and tasks: 1.1.1 - Highly efficient T7 RNA polymerase, 1.3.1. - Design and study of RNA analogs to modulate nuclease activity in the cap-snatching mechanism by influenza polymerase, 1.3.2. - Design and study of RNA analogs to modulate helicase activity by human SETX to fulfill Objective 1.1 Development of methodology for synthesizing modified RNA. You will also participate in Activity 2.2.4 - Biochemical and structural (cryo-EM) analysis of Dicer and Argonaute proteins with or without different substrates.
Requirements:
We offer:
Additional information:
Start date: The initial start date is April 1st, 2025, or upon agreement
Job type: part-time
Duration: initial full-time fixed-term contract for one year, with the possibility of extension
Application deadline: 8.3.2025 or until the position is filled
Applications, including a CV, a brief motivation letter, and contacts for at least two references, should be sent via e-application.
Suitable candidates will be contacted to arrange an interview. Please note that if you are not contacted within 5 weeks, we have preferred candidates who more closely meet the criteria. Thank you for your understanding.
CEITEC MU is a proud holder of the European Commission's HR Excellence in Research Award. We were the first research institution in the Czech Republic to secure one of the top places in the Company of the Year: Equal Opportunities 2020 competition.
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