Postdoctoral Researcher in in Membrane Spatial Biology

Postdoctoral Researcher in in Membrane Spatial Biology

Postdoctoral Researcher in in Membrane Spatial Biology

Do you want to contribute to top quality medical research?

The Nanomedicine and Spatial Biology Lab at the Department of Physiology and Pharmacology, Karolinska Institutet, is seeking a talented research specialist to join our team. Our research investigates the role of spatial organization in biological processes. To study this, we develop

DNA nanotechnology-based tools to map and manipulate membrane protein nanodomains (e.g. Spratt, Dias et al., Nature Nanotechnology, 2024; Ambrosetti et al., Nature Nanotechnology, 2021; Shaw, Lundin et al., Nature Methods, 2014).

Description of the subject area

Membrane proteins assemble into dynamic nanodomains that regulate receptor signaling and intracellular trafficking. Disruption of this spatial organization is implicated in diseases such as cancer and neurodegeneration, which makes nanodomains promising biomarkers and therapeutic targets. To realize this potential, we use DNA nanotechnology to develop methods for large-scale, high-resolution mapping of the composition and nanoscale architecture of membrane protein nanodomains in both physiological and disease states.

Your mission

As a research specialist, you will drive innovative projects at the intersection of spatial biology and nanomedicine. You will develop novel methods to analyze the spatial organization of proteins, both in cell populations and in single cells. The work includes the design and production of DNA nanostructures, cell biology experiments, advanced microscopy and large-scale data analysis.

Eligibility requirements

For employment as postdoc t at Karolinska Institutet, the eligibility requirements stated in the Guidelines for non-teaching positions at Karolinska Institutet are applied in relation to the established profile of employment.

Assessment criteria

It is particularly meritorious that the applicant has shown

• expertise in DNA nanotechnology
• expertise in cell biology
• expertise in computational biology
• experience of in vivo studies in zebrafish and mouse models.

It is meritorious that the applicant has shown

• expertise in the design, production and purification of DNA origami nanostructures
• experience with methods for analyzing cellular responses, including single-cell RNA sequencing (scRNA-seq) and advanced microscopy.

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna, Biomedicum

https://ki.se/en/research/research-areas-centres-and-networks/research-groups/nanomedicine-and-spatial-biology-teixeira-lab

Application

We prefer that your application is written in English, but you may also apply in Swedish. The application must contain the following documents: PhD certificate, CV, qualifications and a letter of intent.

The application must be submitted through the Varbi recruitment system.

For permanent employment, Karolinska Institutet applies a six-month probationary period.

Want to make a difference? Join us and contribute to better health for all!

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